Okay, my Mega Drive Top 10.

1. Alisia Dragoon
2. Sonic The Hedgehog
3. Bari-Arm (Mega CD)
4. Bare Knuckle 2
5. Fatal Fury 2
6. Comix Zone
7. Panorama Cotton
8. M.U.S.H.A.
9. Aladdin
10. Sonic & Knucles

My Top 10:

1. Sonic the Hedgehog 3 + Knuckles - Both games locked together play the game as the developers originally intended the full game to play, best Sonic game of all time, IMO.

2. Sonic the Hedgehog - The original is the one I played the most as it came with my Sega Genesis. So I have a lot of nostalgia attached to it.

3. X-Men 2: The Clone Wars - One of the best X-Men games and one of the best beat-em ups ever made, IMO. Fantastic graphics and sound for the Sega Genesis, great level design, and true to the comics of the time. Plus you were able to play as the mighty Magneto!

4. Golden Axe - I loved this game in the arcade long before I ever played it on the Genesis. So the best home version of it HAD to be in my collection as soon as I got a Genesis.

5. Lords of Thunder (Sega CD) - Saw other Sega CD entries on other people's lists, so I figured it was fair game. Best shmup I've EVER played, as far as I'm concerned. Addicting, challenging, precise controls, great graphics, interesting setting, and fan-freaking-tastic guitar-driven soundtrack.

6. Vectorman - I know, it's kind of a Mega Man rip-off, but it's a good one! It's just plain fun to navigate the labyrinth-esque levels while blasting through robots.

7. Altered Beast - Like Golden Axe, this was an old arcade favorite of mine. So I had to have it in my collection immeadiatly. And how cool is it to turn into a beast and just dominate in that game?

8. Raiden Trad - I love shmups, and this one was my favorite on the Genesis. This was again, because it was an old arcade favorite of mine. I used to play the arcade frequently at a local pizza place that's no longer around, sadly.

9. Maximum Carnage (Spider-Man & Venom) - Tough-as-nails beat-em up with some great graphics, sound, and controls. This one follows the Spider-Man comic storyline of the same name, which back then I was OBSESSED with Spider-Man comics, especially ones with Venom & Carnage.

10. Comix Zone - I'm a lifelong comic book fan, so the style of this game just called out to me. Such a tough game, though. I STILL haven't made it any further than the Monk Monastary level after the Alien Pods level (Level 3, I think?).

1. Sonic 3 and Knuckles
2. Shinobi 3
3. X-Men 2
4. Maxium Carnage
5.Phantasy Star 3
6. Super Street Fighter 2
7.Mortal Kombat (CD)
8.Anamaniacs
9. Vectorman
10.Contra Hard Corps

Genesis is a great system and I agree while its difficult to list your favorite 10 games, at least I can share a couple of the best franchises....
--Streets of Rage series
--Cool Spot series
--Golden Axe series
--Vectorman series
--Sonic series (of course, but better with Knuckles)
Also shout out to games like Ecco, Bonanza Bros, and NBA Hangtime